I've only sent a few of my sims on holiday, but have a problem with the two sets of ancient ruin community lots - Ancient Ruins of Numchuck and Majestic Ruins of Jumbok IV on Twikii Island - plus the secret lot in Takemizu Village. Each time my sim arrives at one of these lots the game sends him straight back to his hotel before he's had a chance to look around
The other problems I've had include wristwatches being stuck on my sim (in CAS anyway), and a vampire cured with Vampirocillin from the Matchmaker still walking around with her arm over her face:
The vamp in question is one of the Grand Vampires. Other than the issues I've mentioned, I haven't noticed any more serious problems - yet.