I had this same thing happen! I just had the one female that couldn't interact with a male. After trying everything posted here and everything else I could think of I just had my female move out of the house.(yes, leaving the husband and kids) After moving her into another house, I had her call her husband (that worked) invite over and propose move-in, he came with the kids. I have no idea what was going on and why this worked for me...It is something you can try? Good luck.
really well i tried everything i cloned her useing a hack i kill her resurrected her and everything but her clone works she can talk to everyone nd nothing happens but the thing is the clone doesnt have everything the original has like memory or the vacations shes been on and stuff like that but i guess ima kill her and whenever i wanna remember what i did with her i will resurrect her and make her clone mary her husband and use the family hack to make her the mom of the originals childs.